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An American woman died of respiratory failure in her Dominican Republic hotel room days before a Maryland couple was found dead of the same cause at the same resort, a hotel staff member told ABC News.

Miranda Schaupp-Werner was found dead at the Grand Bahía Príncipe hotel in La Romana on May 25 — five days before Edward Nathaniel Holmes, 63, and Cynthia Ann Day, 49, were found dead in their hotel room.

Schaup-Werner died of respiratory failure and pulmonary edema, according to the hotel. An autopsy performed on the couple determined that they died of the same causes, according to the Dominican Republic National Police.

PHOTO: American couple Edward Nathael Holmes, 63, and Cynthia Ann Day, 49, died while staying at the Playa Nueva Romana resort in the Dominican Republic.bahia-principe.com
American couple Edward Nathael Holmes, 63, and Cynthia Ann Day, 49, died while staying at the Playa Nueva Romana resort in the Dominican Republic.

The U.S. Department of State confirmed to ABC News that Schaupp-Werner was an American. Police said they are aware of Schaupp-Werner’s death but have not opened a criminal investigation into it because her death does not appear to be suspicious.

Police are investigating the deaths of the couple, as they were initially considered suspicious since Holmes complained of chest pains the day he died but refused to see the doctor that was called, police said.

PHOTO: A photograph posted to Facebook on May 28, 2019, shows Americans Nathaniel Edward Holmes and Cynthia Ann Day on vacation in the Dominican Republic, before they were found dead at a hotel there in late May 2019.Nathaniel Holmes/Facebook
A photograph posted to Facebook on May 28, 2019, shows Americans Nathaniel Edward Holmes and Cynthia Ann Day on vacation in the Dominican Republic, before they were found dead at a hotel there in late May 2019.

The couple’s bodies showed no signs of violence, police said.

Holmes and Day arrived at the hotel on May 25 and were scheduled to depart on Thursday, police said. They were found unresponsive by hotel staff after they missed their scheduled check-out time on Thursday, according to a statement from the hotel.

“We offer our sincerest condolences to the family on their loss,” a State Department official said on regards to Holmes’ and Day’s deaths.

Additional information was not immediately available.

ABC News’ Conor Finnegan and Aicha El Hammar Castano contributed to this report.

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